Technical Reports & Scientific Studies on Chlorine Dioxide

This page serves as the scientific backbone of the ClO2 cleaning system. Here you’ll find a curated collection of peer-reviewed studies, regulatory guidance documents, and applied technical reports that examine how chlorine dioxide works — at the molecular level — and how it performs in real-world cleaning, sanitation, deodorization, and air purification applications. While chlorine dioxide has been studied extensively for decades, this library focuses specifically on data that is relevant to modern, residue-free, low-toxicity cleaning systems using stabilized chlorine dioxide tablets.

Why This Research Matters

Separating Marketing Claims from Measurable Outcomes

Cleaning products often rely on broad claims like “kills 99.9%” or “hospital grade” without providing transparent evidence. The studies presented here document measured microbial reduction, oxidation behavior, byproduct formation, and surface compatibility, allowing users to evaluate chlorine dioxide based on data — not slogans.

Bridging Science and Practical Applications

Many chlorine dioxide studies originate in water treatment, food safety, or medical research. This page connects that research to real-world surface cleaning, air treatment, odor control, and touchpoint sanitation, translating technical findings into practical relevance.

What Types of Documents You’ll Find

Peer-Reviewed Scientific Studies

These include laboratory and field studies published in scientific journals examining:

Microbial inactivation mechanisms
Oxidation of odor-causing compounds
Biofilm disruption
Airborne pathogen and particulate reduction

Technical & Engineering Reports

Applied reports focusing on:

Concentration (ppm) effectiveness
Contact time requirements
Stability and degradation behavior
Material and surface compatibility

Regulatory & Safety References

Documents and excerpts from:

EPA and international regulatory bodies
Occupational exposure guidelines
Drinking water and food-contact safety standards

These references help clarify what chlorine dioxide is — and is not — from a safety and compliance perspective.

Study: Antiviral Effect of Chlorine Dioxide Against Influenza Virus and Its Application for Infection Control

Key Points from Study Abstract:

The study was prompted the outbreaks of Avian Influenza (H5N1) and Swine Flu (H1N1) and a search for a better means of providing surface AND air disinfection.
The desire to restrict the spread of infection is the core and reasonable objective.
Recent (other) studies had demonstrated the superior ability of ClO2 to denature proteins, so this raised its ranking among disinfection options when this study was conducted in 2010.
The additional fact that it was active in this antiviral activity at a gaseous dose of just 0.03ppm also made it a very attractive option. This is compared to the OSHA standard that a building occupant can be exposed to up to 0.1ppm for 8 hours in any given day.

Key Points from Study Conclusion:

The study cited that ClO2 is effective against many viruses (see section 3.1) at under 10ppm and in less than 1 minute.
The study also cited that to achieve the same level of efficacy from Sodium Hypochlorite (bleach) required 10 TIMES the concentration (100 ppm).
The study showed that at less than 1/3 of the OSHA weighted average exposure to ClO2 gas, that ClO2 was able to inactivate Influenza without any harm to mice.
The study also showed that when the gas was released in a cafeteria of school children at these levels, no gas was noticed and absenteeism dropped - children stayed healthier.

Read the Entire Study Report

Efficacy and Safety Evaluation of a Chlorine Dioxide Solution

Reason for Inclusion for Your Evaluation:

In this study they establish some important facts:
All bacteria tests were at half of the above concentration (5 ppm), fungi evaluations were at 20 ppm.
ClO2 is non-toxic in drinking water at levels of up to 40 ppm.
The ClO2 product used here was produced from food-grade salt.

Read this Additional Study

Article from Best Vet Solutions: Why Chlorine Dioxide Should be Your Choice for [Continuous Poultry] Water Sanitation

Excerpts from the Article:

'Chlorine Dioxide technology has really taken off over the past couple of years in the poultry industry and has shown to be a great alternative to Chlorine and even stabilized Hydrogen Peroxide for continuous water sanitation.'
'ClO2 is chemically quite different from Chlorine. ClO2 only has 2/3 the oxidation potential of Chlorine or stabilized Hydrogen Peroxide but it has 2.5 times more oxidation capacity compared to both of those chemicals.'
'ClO2 is NOT pH dependent like Chlorine and can disinfect your water from a pH of 2 to 10. It is far less corrosive on equipment compared to Chlorine.'
'ClO2 can work on and eliminate biofilm, take out sulfur odors and helps eliminate mineral build up and filtering / removing iron out of your water becomes more effective.'
'ClO2 technology over other products is because of CLO2’s ability to be a ‘selective’ oxidizer when working in your water system.'
'CLO2 can generally be effective at 5 ppm TOTAL and 1 ppm FREE residual activity in your water.'

Read the Entire Study Article

Complete List of Studies: Against What Microbes is Chlorine Dioxide Effective as a Biocide?

Disclaimer:

This list has been available in many forms and on numerous ClO2 sites, showing a massive number of studies as to the effectiveness of ClO2 on various pathogenic and non-pathogenic microbes. We do not know it original author, nor make any claim as to its full veracity, only that it may be an excellent starting point for a study of your own.

View the Entire List of Studies

Budapest Medical Hypotheses: Can Chlorine Dioxide Prevent the Spreading of Coronavirus or Other Viral Infections

Disclaimer:

This article presents the opinion of what we believe to be a reputable and accredited team of scientists from Hungary, who are expressing their opinion and hypothesis. We present it here for your own review and conclusions.

Read the View of The Authors